A Pd-Catalyzed Site-Controlled Isomerization of Terminal Olefins

Wenlong Ren; Fei Sun; Jianxiao Chu; Yian Shi

doi:10.1021/acs.orglett.0c00168

A Pd-Catalyzed Site-Controlled Isomerization of Terminal Olefins

Org Lett. 2020 Mar 6;22(5):1868-1873. doi: 10.1021/acs.orglett.0c00168. Epub 2020 Feb 11.

Authors

Wenlong Ren¹, Fei Sun¹, Jianxiao Chu¹, Yian Shi^{1

2}

Affiliations

¹ Institute of Natural and Synthetic Organic Chemistry, Changzhou University, Changzhou 213164, China.
² Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.

PMID: 32043881
DOI: 10.1021/acs.orglett.0c00168

Abstract

An effective Pd-catalyzed isomerization of olefins with 2-PyPPh₂ as the ligand is described. A wide variety of trans-2-olefins bearing various functional groups can be obtained with high regio- and stereoselectivity under mild reaction conditions. The ligand is crucial for the reaction.