Germline variants in predisposition genes in children with Down syndrome and acute lymphoblastic leukemia

Blood Adv. 2020 Feb 25;4(4):672-675. doi: 10.1182/bloodadvances.2019001216.

Abstract

  1. Rare and pathogenic germline variants, including in IKZF1, contribute to acute lymphoblastic leukemia in children with Down syndrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Down Syndrome* / genetics
  • Germ Cells
  • Germ-Line Mutation
  • Humans
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics