A Natural Product Puts Malaria on a Low-Fat Diet

Daniel Lucy; Leran Zhang; Edward W Tate

doi:10.1016/j.chembiol.2020.02.001

A Natural Product Puts Malaria on a Low-Fat Diet

Cell Chem Biol. 2020 Feb 20;27(2):137-139. doi: 10.1016/j.chembiol.2020.02.001.

Authors

Daniel Lucy¹, Leran Zhang¹, Edward W Tate²

Affiliations

¹ Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK.
² Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK. Electronic address: e.tate@imperial.ac.uk.

PMID: 32084335
DOI: 10.1016/j.chembiol.2020.02.001

Abstract

In this issue of Cell Chemical Biology, Yoo et al. (2020) use chemical proteomics to identify target proteins for the potent antimalarial natural product Salinipostin A. Polypharmacology from targeting multiple parasite serine hydrolases and lipases limits resistance to the compound, making this a promising new approach for treating malaria.

Publication types

Comment

MeSH terms

Animals
Antimalarials* / pharmacology
Bridged Bicyclo Compounds, Heterocyclic
Diet, Fat-Restricted
Hydrolases
Lipid Metabolism
Malaria* / drug therapy
Parasites*
Serine

Substances

Antimalarials
Bridged Bicyclo Compounds, Heterocyclic
salinipostin A
Serine
Hydrolases