L-657,398, a novel antifungal agent: fermentation, isolation, structural elucidation and biological properties

R E Schwartz; J Liesch; O Hensens; L Zitano; S Honeycutt; G Garrity; R A Fromtling; J Onishi; R Monaghan

doi:10.7164/antibiotics.41.1774

L-657,398, a novel antifungal agent: fermentation, isolation, structural elucidation and biological properties

J Antibiot (Tokyo). 1988 Dec;41(12):1774-9. doi: 10.7164/antibiotics.41.1774.

Authors

R E Schwartz¹, J Liesch, O Hensens, L Zitano, S Honeycutt, G Garrity, R A Fromtling, J Onishi, R Monaghan

Affiliation

¹ Merck Sharp & Dohme Research Laboratories, Rahway, N.J.

PMID: 3209471
DOI: 10.7164/antibiotics.41.1774

Abstract

L-657,398 is a broad spectrum antifungal agent isolated from solid fermentation or from the mycelium of the liquid fermentation of Aspergillus ochraceus. Structurally, the compound is a novel pyrollidine related to anisomycin.

MeSH terms

Anisomycin / analogs & derivatives
Anisomycin / isolation & purification*
Anisomycin / pharmacology
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Aspergillus / metabolism*
Chemical Phenomena
Chemistry
Fermentation
Pyrrolidines / isolation & purification*

Substances

Antifungal Agents
Pyrrolidines
preussin
Anisomycin