Cardiovascular autonomic neuropathy: A silent killer with long reach

Lynn Ang; Brendan Dillon; Kara Mizokami-Stout; Rodica Pop-Busui

doi:10.1016/j.autneu.2020.102646

Cardiovascular autonomic neuropathy: A silent killer with long reach

Auton Neurosci. 2020 May:225:102646. doi: 10.1016/j.autneu.2020.102646. Epub 2020 Feb 11.

Authors

Lynn Ang¹, Brendan Dillon², Kara Mizokami-Stout¹, Rodica Pop-Busui³

Affiliations

¹ Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, United States of America.
² University of Michigan Medical School, Ann Arbor, MI, United States of America.
³ Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: rpbusui@umich.edu.

PMID: 32106052
DOI: 10.1016/j.autneu.2020.102646

Abstract

Cardiovascular autonomic neuropathy (CAN) is a common and deadly complication of diabetes mellitus, which is frequently overlooked in clinical practice due to its characteristic subtle presentation earlier in disease. Yet, timely detection of CAN may help implementation of tailored interventions to prevent its progression and mitigate the risk of associated complications, including cardiovascular disease (CVD), cardiac arrhythmias, myocardial dysfunction leading to congestive heart failure and all-cause mortality. This review highlights current CAN epidemiology trends, novel mechanisms linking CAN with other diabetes complications and current recommendations for diagnosis and management of the disease in the clinical setting.

Keywords: Cardiovascular autonomic dysfunction; Cardiovascular autonomic neuropathy; Cardiovascular disease; Diabetes mellitus.

Publication types

Review