The mysterious life of the plant trans-Golgi network: advances and tools to understand it better

J Microsc. 2020 Jun;278(3):154-163. doi: 10.1111/jmi.12881. Epub 2020 Mar 20.

Abstract

By being at the interface of the exocytic and endocytic pathways, the plant trans-Golgi network (TGN) is a multitasking and highly diversified organelle. Despite governing vital cellular processes, the TGN remains one of the most uncharacterized organelle of plant cells. In this review, we highlight recent studies that have contributed new insights and to the generation of markers needed to answer several important questions on the plant TGN. Several drugs specifically affecting proteins critical for the TGN functions have been extremely useful for the identification of mutants of the TGN in the pursuit to understand how the morphology and the function of this organelle are controlled. In addition to these chemical tools, we review emerging microscopy techniques that help visualize the TGN at an unpreceded resolution and appreciate the heterogeneity and dynamics of this organelle in plant cells.

Keywords: Microscopy; Super resolution microscopy; Traffic inhibitors; Trans-Golgi network.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biomarkers
  • Brefeldin A / pharmacology
  • Cell Membrane / physiology
  • Cytoskeleton / physiology
  • Limonins / pharmacology
  • Macrolides / pharmacology
  • Microscopy*
  • Monensin / pharmacology
  • Plant Cells / physiology*
  • Plant Roots / physiology
  • Protein Transport
  • Time-Lapse Imaging*
  • Wortmannin / pharmacology
  • trans-Golgi Network / drug effects*
  • trans-Golgi Network / physiology*

Substances

  • Biomarkers
  • Limonins
  • Macrolides
  • Brefeldin A
  • concanamycin A
  • Monensin
  • Wortmannin