Periodic cessation of respiratory effort during sleep in adult rats

Physiol Behav. 1988;43(2):229-34. doi: 10.1016/0031-9384(88)90243-0.

Abstract

Using a noninvasive technique which measures respiration as a function of chest and abdominal movement, it was found that adults rats have periodic cessations of respiratory effort during the daytime. In a preliminary study, male Fischer-344 rats had respiratory pauses of 2.4-2.6 seconds duration, which tended to be more frequent in older (22-month) compared to young adult (3-month) rats. Respiratory rate was lower and respiratory volume greater in the 22-month-old animals. In a more detailed study of 3-month-old male Sprague-Dawley rats, respiratory pauses were divided into two types: those preceded by a large inspiration ("sighs") and those which were not. The latter, which appear to be most analogous to human apneas of clinical interest, occurred in all animals studied, with a frequency of 13 to 26 events during six hour recordings. These pauses varied in duration from 2.0 to 6.1 seconds and were most frequent and longest in REM sleep.

MeSH terms

  • Aging
  • Animals
  • Inhalation
  • Rats
  • Rats, Inbred F344 / growth & development*
  • Rats, Inbred Strains / growth & development*
  • Respiration*
  • Sleep / physiology*
  • Sleep, REM / physiology
  • Time Factors
  • Wakefulness / physiology