[Research progress in the application of anti-IgE antibody for allergic asthma in school-age children]

Zhonghua Er Ke Za Zhi. 2020 Mar 2;58(3):255-258. doi: 10.3760/cma.j.issn.0578-1310.2020.03.023.
[Article in Chinese]

Abstract

支气管哮喘为儿童时期常见的慢性气道异质性疾病,严重影响患儿生长发育及生活质量。研究表明IgE介导的Ⅰ型变态反应在其发病机制中起着至关重要的作用。奥马珠单克隆抗体是已上市的抗IgE单克隆抗体,可与血液中游离IgE特异性结合,从而阻断过敏性炎症反应,已作为一类精准靶向药物为哮喘患儿治疗提供新的选择。本文就抗IgE单克隆抗体在学龄期过敏性哮喘患儿中的临床应用研究进行综述。.

MeSH terms

  • Antibodies, Anti-Idiotypic / therapeutic use*
  • Asthma* / drug therapy
  • Asthma* / immunology
  • Child
  • Humans
  • Hypersensitivity
  • Immunoglobulin E / immunology*
  • Treatment Outcome

Substances

  • Antibodies, Anti-Idiotypic
  • anti-IgE antibodies
  • Immunoglobulin E