Immunotherapy in Multiple Myeloma

Cells. 2020 Mar 3;9(3):601. doi: 10.3390/cells9030601.

Abstract

Multiple myeloma is a complex disease and immune dysfunction has been known to play an important role in the disease pathogenesis, progression, and drug resistance. Recent efforts in drug development have been focused on immunotherapies to modify the MM disease process. Here, we summarize the emerging immunotherapies in the MM treatment landscape.

Keywords: ADC; BiTE; CAR-T; IMiD; checkpoint inhibitor; immunotherapy; monoclonal antibody; multiple myeloma; vaccine; virotherapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibodies, Monoclonal / pharmacology
  • Antibodies, Monoclonal / therapeutic use*
  • Humans
  • Immunotherapy / methods*
  • Multiple Myeloma / drug therapy*

Substances

  • Antibodies, Monoclonal