Stressful Beginnings with Long-Term Consequences

Camila Rosat Consiglio; Petter Brodin

doi:10.1016/j.cell.2020.02.021

Stressful Beginnings with Long-Term Consequences

Cell. 2020 Mar 5;180(5):820-821. doi: 10.1016/j.cell.2020.02.021.

Authors

Camila Rosat Consiglio¹, Petter Brodin²

Affiliations

¹ Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Stockholm SE-17121, Sweden.
² Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Stockholm SE-17121, Sweden; Unit of Pediatric Rheumatology, Karolinska University Hospital, Solna SE-17176, Sweden. Electronic address: petter.brodin@ki.se.

PMID: 32142672
DOI: 10.1016/j.cell.2020.02.021

Abstract

Early-life stress can have long-term health consequences, but the mechanisms of this are unknown. In this issue of Cell, Hong et al. demonstrate one such mechanism linking perinatal corticosteroid exposure to reduced CD8⁺ T cell function later in life and impaired anti-cancer and anti-bacterial immune responses.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes*
Female
Glucocorticoids*
Humans
Pregnancy
Stress, Psychological

Substances

Glucocorticoids