Flavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis

J Virol. 2020 May 18;94(11):e00104-20. doi: 10.1128/JVI.00104-20. Print 2020 May 18.

Abstract

Flaviviruses encode one, two, or no N-linked glycosylation sites on their envelope proteins. Glycosylation can impact virus interactions with cell surface attachment factors and also may impact virion stability and virus replication. Envelope protein glycosylation has been identified as a virulence determinant for multiple flaviviruses, but the mechanisms by which glycosylation mediates pathogenesis remain unclear. In this Gem, we summarize current knowledge on flavivirus envelope protein glycosylation and its impact on viral infection and pathogenesis.

Keywords: DC-SIGN; DC-SIGNR; West Nile virus; Zika virus; dengue virus; flavivirus; glycosylation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Flavivirus Infections / metabolism*
  • Flavivirus Infections / pathology
  • Flavivirus* / pathogenicity
  • Flavivirus* / physiology
  • Glycosylation
  • Humans
  • Viral Envelope Proteins / metabolism*
  • Virus Replication*

Substances

  • Viral Envelope Proteins