Longitudinal Study of CPK-MB and Echocardiographic Measures of Myocardial Dysfunction in Pediatric Sepsis: Are Patients with Shock Different from Those without?

Arun K Baranwal; Geddam Deepthi; Manoj K Rohit; Muralidharan Jayashree; Suresh K Angurana; Praveen Kumar-M

doi:10.5005/jp-journals-10071-23340

Longitudinal Study of CPK-MB and Echocardiographic Measures of Myocardial Dysfunction in Pediatric Sepsis: Are Patients with Shock Different from Those without?

Indian J Crit Care Med. 2020 Feb;24(2):109-115. doi: 10.5005/jp-journals-10071-23340.

Authors

Arun K Baranwal¹, Geddam Deepthi², Manoj K Rohit³, Muralidharan Jayashree⁴, Suresh K Angurana⁴, Praveen Kumar-M⁵

Affiliations

¹ Division of Pediatric Critical Care and Pediatric Cardiac Care Unit, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
² Trinity Hospital, Nellore, Andhra Pradesh, India.
³ Department of Cardiology, Advanced Cardiac Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁴ Division of Pediatric Critical Care, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁵ Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

Background: Sepsis-induced myocardial dysfunction has implications on outcome. For lack of echocardiography in resource-limited settings, myocardial biomarkers may be an alternative monitoring tool.

Objective: This study was planned to explore the longitudinal behavior of creatine phosphokinase-MB (CPK-MB) in children with sepsis with and without shock, and its correlation with clinical and echocardiographic parameters over the first 10 days.

Design: Prospective observational study.

Setting: Tertiary care hospital in a lower-middle-income economy of South Asia.

Patients: Children (3 months to 12 years) with nonshock sepsis (NSS) (n = 40) and septic shock survivors (SSSs) (n = 40) after optimal resuscitation. Patients with catecholamine refractory shock, preexisting heart disease, and cardiorespiratory event within the past 1 month were excluded from the study.

Measurements and main results: Pediatric logistic organ dysfunction (PeLOD) score, vasoactive inotrope score (VIS), CPK-MB, and echocardiographic measures of myocardial function were recorded on days 1, 3, 7, and 10. Echocardiography was repeated at 1 month. Both groups were similar at baseline. The SSSs had higher CPK-MB (180 vs 53 IU/L; p < 0.001) and PeLOD score (2 ± 0.4 vs 11.7 ± 5.1, p < 0.001) on day 1 compared to the NSS children. More than half of the SSS and none of the NSS patients had myocardial dysfunction. Reduction in CPK-MB over 10 days correlated well with improvement in PeLOD (p < 0.01), VIS (p = 0.04), and echocardiographic measures of myocardial dysfunction (p < 0.05) among SSSs. At 1 month follow-up, all had normal echocardiography.

Conclusion: The SSSs had markedly elevated CPK-MB, and its fall paralleled the improvement in clinical status and myocardial dysfunctions. The CPK-MB could be a potential monitoring tool for septic cardiomyopathy in resource-limited settings.

How to cite this article: Baranwal AK, Deepthi G, Rohit MK, Jayashree M, Angurana SK, Kumar-M P. Longitudinal Study of CPK-MB and Echocardiographic Measures of Myocardial Dysfunction in Pediatric Sepsis: Are Patients with Shock Different from Those without? Indian J Crit Care Med 2020;24(2):109-115.

Keywords: Cardiac biomarkers; Creatine kinase-MB; Echocardiography; Myocardial dysfunction; Sepsis; Septic shock.