Stemtuberolines A-G, new alkaloids from Stemona tuberosa and their anti-TMV activity

Zhan-Xing Hu; Qiao An; Hong-Yu Tang; Chun-Mao Yuan; Ya-Nan Li; Yu Zhang; Xiao-Jiang Hao

doi:10.1016/j.fitote.2020.104572

Stemtuberolines A-G, new alkaloids from Stemona tuberosa and their anti-TMV activity

Fitoterapia. 2020 Jun:143:104572. doi: 10.1016/j.fitote.2020.104572. Epub 2020 Mar 26.

Authors

Zhan-Xing Hu¹, Qiao An¹, Hong-Yu Tang², Chun-Mao Yuan¹, Ya-Nan Li¹, Yu Zhang³, Xiao-Jiang Hao⁴

Affiliations

¹ State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
² State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: zhangyu@mail.kib.ac.cn.
⁴ State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: haoxj@mail.kib.ac.cn.

PMID: 32224153
DOI: 10.1016/j.fitote.2020.104572

Abstract

Three new tuberostemoamide-type alkaloids, stemtuberolines A-C (1-3), four new stenine-type alkaloids, stemtuberolines D-G (4-7), together with five known Stemona alkaloids (8-12), were isolated from the roots of Stemona tuberosa. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis. Stemtuberoline C (3) exhibited significant anti-TMV activity with an inhibition rate of 60.48% at the concentration of 50 μg/mL, while that of ningnamycin, the positive control, was 52.89%.

Keywords: Anti-TMV; Stemona tuberosa; Stenine-type alkaloid; Tuberostemoamide-type alkaloid.

MeSH terms

Alkaloids / isolation & purification
Alkaloids / pharmacology*
Antiviral Agents / isolation & purification
Antiviral Agents / pharmacology*
China
Molecular Structure
Nicotiana / virology
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
Plant Diseases / prevention & control
Plant Diseases / virology
Plant Roots / chemistry
Stemonaceae / chemistry*
Tobacco Mosaic Virus / drug effects*

Substances

Alkaloids
Antiviral Agents
Phytochemicals
stenine