Targeting TGFβ Signalling in Cancer: Toward Context-Specific Strategies

Rhiannon French; Yuliang Feng; Siim Pauklin

doi:10.1016/j.trecan.2020.03.010

Targeting TGFβ Signalling in Cancer: Toward Context-Specific Strategies

Trends Cancer. 2020 Jul;6(7):538-540. doi: 10.1016/j.trecan.2020.03.010. Epub 2020 Apr 8.

Authors

Rhiannon French¹, Yuliang Feng¹, Siim Pauklin²

Affiliations

¹ Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Old Road, University of Oxford, Headington, Oxford OX3 7LD, UK.
² Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Old Road, University of Oxford, Headington, Oxford OX3 7LD, UK. Electronic address: siim.pauklin@ndorms.ox.ac.uk.

PMID: 32278685
DOI: 10.1016/j.trecan.2020.03.010

Abstract

The transforming growth factor beta (TGFβ) signalling pathway regulates a range of important cellular processes in a context-dependent manner. Recent discoveries have provided important insights into the regulation of the TGFβ pathway and its change from an antitumorigenic to a protumorigenic pathway. These findings may have important implications for cancer stem cell (CSC) functions and therapeutic strategies.

Keywords: Smad2/3; TGFβ signalling pathway; cancer stem cells; epithelial-to-mesenchymal transition; gene expression; pancreatic tumorigenesis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Neoplasms*
Neoplastic Stem Cells
Signal Transduction
Transforming Growth Factor beta*

Substances

Transforming Growth Factor beta

Abstract

Publication types

MeSH terms

Substances

Grants and funding