Reducing Stress PERKs up Anti-tumor Immunity

Marie-Eve Charbonneau; Mary X D O'Riordan

doi:10.1016/j.immuni.2020.03.012

Reducing Stress PERKs up Anti-tumor Immunity

Immunity. 2020 Apr 14;52(4):575-577. doi: 10.1016/j.immuni.2020.03.012.

Authors

Marie-Eve Charbonneau¹, Mary X D O'Riordan²

Affiliations

¹ Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
² Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: oriordan@umich.edu.

Abstract

Myeloid-derived suppressor cells (MDSCs) can promote tumor progression. In this issue of Immunity, Mohamed et al. show that the unfolded protein response sensor, PERK, enhances MDSC-mediated immunosuppression through the NRF2 transcription factor, preventing oxidative damage, mitochondrial DNA release, and DNA sensor-STING-dependent type I interferon production.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Immune Tolerance
Immunosuppression Therapy
Myeloid Cells* / immunology
Myeloid-Derived Suppressor Cells* / immunology
Unfolded Protein Response

Grants and funding

R21 AI101777/AI/NIAID NIH HHS/United States