Roadmap for the Emerging Field of Cancer Neuroscience

Michelle Monje; Jeremy C Borniger; Nisha J D'Silva; Benjamin Deneen; Peter B Dirks; Faranak Fattahi; Paul S Frenette; Livia Garzia; David H Gutmann; Douglas Hanahan; Shawn L Hervey-Jumper; Hubert Hondermarck; Jonathan B Hurov; Adam Kepecs; Sarah M Knox; Alison C Lloyd; Claire Magnon; Jami L Saloman; Rosalind A Segal; Erica K Sloan; Xin Sun; Michael D Taylor; Kevin J Tracey; Lloyd C Trotman; David A Tuveson; Timothy C Wang; Ruth A White; Frank Winkler

doi:10.1016/j.cell.2020.03.034

Roadmap for the Emerging Field of Cancer Neuroscience

Cell. 2020 Apr 16;181(2):219-222. doi: 10.1016/j.cell.2020.03.034.

Authors

Michelle Monje¹, Jeremy C Borniger², Nisha J D'Silva³, Benjamin Deneen⁴, Peter B Dirks⁵, Faranak Fattahi⁶, Paul S Frenette⁷, Livia Garzia⁸, David H Gutmann⁹, Douglas Hanahan¹⁰, Shawn L Hervey-Jumper¹¹, Hubert Hondermarck¹², Jonathan B Hurov¹³, Adam Kepecs², Sarah M Knox¹⁴, Alison C Lloyd¹⁵, Claire Magnon¹⁶, Jami L Saloman¹⁷, Rosalind A Segal¹⁸, Erica K Sloan¹⁹, Xin Sun²⁰, Michael D Taylor²¹, Kevin J Tracey²², Lloyd C Trotman², David A Tuveson², Timothy C Wang²³, Ruth A White²⁴, Frank Winkler²⁵

Affiliations

¹ Departments of Neurology & Neurological Sciences, Pediatrics, Pathology, Neurosurgery, and Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA. Electronic address: mmonje@stanford.edu.
² Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
³ Department of Periodontics and Oral Medicine, School of Dentistry, Department of Pathology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
⁴ Center for Cell and Gene Therapy, Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
⁵ Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Departments of Surgery and Molecular Genetics, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
⁶ Department of Biochemistry and Biophysics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94115, USA.
⁷ Departments of Medicine and Cell Biology, Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
⁸ Cancer Research Program, Research Institute of the McGill University Health Center and Department of Surgery, McGill University, Montreal, QC, Canada.
⁹ Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
¹⁰ Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology Lausanne, Ludwig Institute for Cancer Research, Swiss Cancer Center Leman, Lausanne, Switzerland.
¹¹ Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94115, USA.
¹² School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia.
¹³ Cygnal Therapeutics, Cambridge, MA 02139, USA.
¹⁴ Program in Craniofacial Biology, Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
¹⁵ MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
¹⁶ UMR1274 (Equipe Cancer et Microenvironnement-INSERM-CEA), Institut de Radiobiologie Cellulaire et Moléculaire, Institut de Biologie François Jacob, Direction de la Recherche Fondamentale, Paris, France.
¹⁷ Departments of Medicine and Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
¹⁸ Department of Neurobiology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
¹⁹ Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia.
²⁰ Departments of Pediatrics and Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA.
²¹ Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Developmental and Stem Cell Biology Program, Departments of Surgery, Laboratory Medicine & Pathology and Medical Biophysics, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
²² The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030, USA.
²³ Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
²⁴ Division of Hematology and Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
²⁵ Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, DKTK & Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.

Abstract

Mounting evidence indicates that the nervous system plays a central role in cancer pathogenesis. In turn, cancers and cancer therapies can alter nervous system form and function. This Commentary seeks to describe the burgeoning field of "cancer neuroscience" and encourage multidisciplinary collaboration for the study of cancer-nervous system interactions.

MeSH terms

Humans
Neoplasms / metabolism*
Nervous System / metabolism*
Neurosciences

Abstract

MeSH terms

Grants and funding