Angiotensin-converting enzyme inhibitors from Salvia elegans Vahl

Nat Prod Res. 2021 Dec;35(23):5344-5349. doi: 10.1080/14786419.2020.1758093. Epub 2020 Apr 29.

Abstract

Phytochemical research of the acetate and methanol extracts of the aerial parts (flowers, leaves and stems) of Salvia elegans allowed to obtain seventeen known compounds (1-17): three of them (4, 5, 14), had already been described for this species, while the others (1-3, 6-13, 15-17) are described for the first time for S. elegans. All isolated compounds were characterized using spectroscopic techniques and mass spectrometry and were evaluated in the Angiotensin I-converting enzyme (ACE) inhibition model, where the phenolic compounds (13, 14 and 15) had the same inhibitory effect as lisinopril at 0.02 mg/mL. The terpenes showed a moderate inhibitory capacity at a concentration of 0.2 mg/mL.

Keywords: Angiotensin-converting enzyme inhibitor; Salvia elegans Vahl; phenolic compounds; terpenes.

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors* / pharmacology
  • Phenols
  • Plant Extracts / pharmacology
  • Plant Leaves
  • Salvia*

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Phenols
  • Plant Extracts