Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

Hai-Qiong Yu; Bao-Qing Sun; Zhang-Fu Fang; Jin-Cun Zhao; Xiao-Yu Liu; Yi-Min Li; Xi-Zhuo Sun; Hong-Feng Liang; Bei Zhong; Zhi-Feng Huang; Pei-Yan Zheng; Li-Feng Tian; Hui-Qi Qu; De-Chen Liu; Er-Yi Wang; Xiao-Jun Xiao; Shi-Yue Li; Feng Ye; Li Guan; Dong-Sheng Hu; Hakon Hakonarson; Zhi-Gang Liu; Nan-Shan Zhong

doi:10.1183/13993003.01526-2020

Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

Eur Respir J. 2020 Aug 27;56(2):2001526. doi: 10.1183/13993003.01526-2020. Print 2020 Aug.

Authors

Hai-Qiong Yu^{1

2}, Bao-Qing Sun^{3

2}, Zhang-Fu Fang^{1

3

4

2}, Jin-Cun Zhao^{3

2}, Xiao-Yu Liu^{1

2}, Yi-Min Li^{3

2}, Xi-Zhuo Sun^{4

2}, Hong-Feng Liang^{5

2}, Bei Zhong^{6

2}, Zhi-Feng Huang^{3

2}, Pei-Yan Zheng³, Li-Feng Tian⁷, Hui-Qi Qu⁷, De-Chen Liu⁸, Er-Yi Wang^{1

4}, Xiao-Jun Xiao¹, Shi-Yue Li³, Feng Ye³, Li Guan⁴, Dong-Sheng Hu⁸, Hakon Hakonarson^{7

9

10}, Zhi-Gang Liu^{1

10}, Nan-Shan Zhong^{11

10}

Affiliations

¹ State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen, China.
² These authors contributed equally to this work.
³ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
⁴ Dept of Respirology and Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
⁵ Yangjiang People's Hospital, Yangjiang, China.
⁶ Dept of Infectious Disease, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China.
⁷ Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁸ Dept of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, China.
⁹ Divisions of Human Genetics and Pulmonary Medicine, Dept of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹⁰ Hakon Hakonarson, Zhi-gang Liu and Nan-shan Zhong are joint lead authors.
¹¹ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China nanshan@vip.163.com.

Abstract

Humoral immune response to SARS-CoV-2 showed an early response of IgA, instead of IgM, in COVID-19 patients. As highlighted by this study, enhanced IgA responses observed in severe COVID-19 might confer damaging effects in severe COVID-19. https://bit.ly/3fA7c1I

Publication types

Letter

MeSH terms

Adult
Aged
Betacoronavirus / immunology*
COVID-19
COVID-19 Testing
Clinical Laboratory Techniques*
Cohort Studies
Coronavirus Infections / blood*
Coronavirus Infections / diagnosis*
Coronavirus Infections / immunology
Female
Humans
Immunity, Humoral / physiology*
Immunoglobulin A / blood*
Male
Middle Aged
Pandemics
Pneumonia, Viral / blood*
Pneumonia, Viral / diagnosis*
Pneumonia, Viral / immunology
SARS-CoV-2

Substances

Immunoglobulin A