Ulcerative colitis: Recent advances in the understanding of disease pathogenesis

Ross J Porter; Rahul Kalla; Gwo-Tzer Ho

doi:10.12688/f1000research.20805.1

Ulcerative colitis: Recent advances in the understanding of disease pathogenesis

F1000Res. 2020 Apr 24:9:F1000 Faculty Rev-294. doi: 10.12688/f1000research.20805.1. eCollection 2020.

Authors

Ross J Porter¹, Rahul Kalla¹, Gwo-Tzer Ho¹

Affiliation

¹ Edinburgh IBD Science Unit, Centre for Inflammation Research, Queens Medical Research Unit, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

Abstract

Inflammatory bowel diseases are common, complex, immune-mediated conditions with a sharply rising global prevalence. While major advances since 2000 have provided strong mechanistic clues implicating a de-regulation in the normal interaction among host genetics, immunity, microbiome, and the environment, more recent progress has generated entirely new hypotheses and also further refined older disease concepts. In this review, we focus specifically on these novel developments in the pathogenesis of ulcerative colitis.

Keywords: Inflammation; Inflammatory Bowel Disease; Mucosal Immunology; Pathogenesis; Ulcerative colitis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Colitis, Ulcerative / genetics
Colitis, Ulcerative / physiopathology*
Female
Humans
Immunity
Male
Microbiota

Grants and funding

GTH is supported by the Leona M. and Harry B. Helmsley Charitable Trust, the Jon Moulton Foundation, Crohn’s Colitis UK and Guts UK Charity.