Cardiac Care of Patients with Cardiac Amyloidosis

Acta Haematol. 2020;143(4):343-351. doi: 10.1159/000506919. Epub 2020 May 14.

Abstract

Cardiac amyloidosis, the majority of cases of which are due to immunoglobulin light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR), affects different aspects of the heart and cardiovascular system. Amyloid-induced cardiomyopathy, clinically manifesting with heart failure and electrophysiological abnormalities, has distinct characteristics compared to non-amyloid cardiomyopathies. Accordingly, specific management strategies are required. This paper will review the cardiovascular manifestations of patients with cardiac amyloidosis and their suggested treatment strategies, emphasizing the importance of multidisciplinary care.

Keywords: Cardiac amyloidosis; Immunoglobulin light chain amyloidosis; Transthyretin amyloidosis.

Publication types

  • Review

MeSH terms

  • Amyloidosis / complications*
  • Amyloidosis / diagnosis
  • Amyloidosis / therapy
  • Cardiomyopathies / diagnosis*
  • Cardiomyopathies / etiology*
  • Cardiomyopathies / therapy*
  • Combined Modality Therapy
  • Disease Management
  • Disease Susceptibility
  • Heart Function Tests
  • Humans
  • Immunoglobulin Light-chain Amyloidosis / complications
  • Phenotype