Bat Influenza Viruses: Making a Double Agent of MHC Class II

Arinjay Banerjee; Karen L Mossman; Matthew S Miller

doi:10.1016/j.tim.2020.04.006

Bat Influenza Viruses: Making a Double Agent of MHC Class II

Trends Microbiol. 2020 Sep;28(9):703-706. doi: 10.1016/j.tim.2020.04.006. Epub 2020 Apr 20.

Authors

Arinjay Banerjee¹, Karen L Mossman¹, Matthew S Miller²

Affiliations

¹ Michael G. DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada.
² Michael G. DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada. Electronic address: mmiller@mcmaster.ca.

Abstract

MHC class II (MHCII) has recently been identified as a cellular receptor for bat influenza viruses. Here, we discuss the possible implications of viral exploitation of this critical host defense molecule and highlight the need for more intense study of bat-influenza virus interactions.

Keywords: MHCII; bats; influenza virus; receptor; transmission; tropism.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chiroptera / virology*
Histocompatibility Antigens Class II / immunology*
Host Microbial Interactions
Humans
Influenza A virus / immunology
Influenza, Human / immunology
Influenza, Human / transmission
Influenza, Human / virology
Orthomyxoviridae / immunology*
Orthomyxoviridae Infections / immunology*
Orthomyxoviridae Infections / transmission*
Orthomyxoviridae Infections / virology
T-Lymphocytes / immunology
Viral Tropism
Zoonoses / virology

Substances

Histocompatibility Antigens Class II