Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor ACE2 and TMPRSS2 in Inflammatory Bowel Disease

Jan Krzysztof Nowak; Jonas Christoffer Lindstrøm; Rahul Kalla; Petr Ricanek; Jonas Halfvarson; Jack Satsangi

doi:10.1053/j.gastro.2020.05.030

Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor ACE2 and TMPRSS2 in Inflammatory Bowel Disease

Gastroenterology. 2020 Sep;159(3):1151-1154.e2. doi: 10.1053/j.gastro.2020.05.030. Epub 2020 May 12.

Authors

Jan Krzysztof Nowak¹, Jonas Christoffer Lindstrøm², Rahul Kalla³, Petr Ricanek⁴, Jonas Halfvarson⁵, Jack Satsangi⁶

Affiliations

¹ Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, UK; Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: jan.nowak@ump.edu.pl.
² Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
³ MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.
⁴ Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.
⁵ Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
⁶ Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, UK; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Electronic address: jack.satsangi@ndm.ox.ac.uk.

No abstract available

Keywords: ACE2, angiotensin-converting enzyme 2; CD, Crohn’s disease; CI, confidence interval; COVID-19, Coronavirus Disease 2019; IBD, inflammatory bowel disease; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; TMPRSS2, transmembrane serine protease 2; UC, ulcerative colitis; hsCRP, high-sensitivity C-reactive protein.

MeSH terms

Age Factors
Angiotensin-Converting Enzyme 2
Betacoronavirus / physiology*
COVID-19
Case-Control Studies
Colon / metabolism
Coronavirus Infections / etiology*
Humans
Ileum / metabolism
Inflammatory Bowel Diseases / metabolism*
Pandemics
Peptidyl-Dipeptidase A / metabolism*
Pneumonia, Viral / etiology*
SARS-CoV-2
Serine Endopeptidases / metabolism*
Spike Glycoprotein, Coronavirus

Substances

Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2
Serine Endopeptidases
TMPRSS2 protein, human

Grants and funding

WT_/Wellcome Trust/United Kingdom