Epigenetic regulation of cortical neurogenesis; orchestrating fate switches at the right time and place

Manal A Adam; Corey C Harwell

doi:10.1016/j.conb.2020.03.012

Epigenetic regulation of cortical neurogenesis; orchestrating fate switches at the right time and place

Curr Opin Neurobiol. 2020 Aug:63:146-153. doi: 10.1016/j.conb.2020.03.012. Epub 2020 May 16.

Authors

Manal A Adam¹, Corey C Harwell²

Affiliations

¹ Department of Neurobiology, Harvard Medical School, Boston, MA 02115, United States.
² Department of Neurobiology, Harvard Medical School, Boston, MA 02115, United States. Electronic address: corey_harwell@hms.harvard.edu.

Abstract

Over the last several decades the field has made tremendous progress in understanding the proliferative behavior of cortical progenitors and the lineage relationships of their clonal progeny. The genetic and epigenetic mechanisms that control the dynamic patterns of gene expression during cortical development are only beginning to be characterized. In this review we highlight the most well characterized epigenetic modifications and their influence on progenitor proliferation and cortical neuron cell fate.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Differentiation
Cell Lineage / genetics
Cerebral Cortex*
Epigenesis, Genetic*
Neurogenesis / genetics
Neurons

Abstract

Publication types

MeSH terms

Grants and funding