Hodkgin lymphoma concomitant of tuberculosis, a therapeutic challenge for multidisciplinary management

Cancer Radiother. 2020 Jul;24(4):335-339. doi: 10.1016/j.canrad.2020.02.005. Epub 2020 May 19.

Abstract

Hodgkin lymphoma (HL) is a disease characterized by a high curability rate, and the treatment benefit-risk balance must be carefully addressed to achieve complete disease control with low risk of long-term toxicities. Most patients are treated with a combination of chemotherapy and radiotherapy, after disease staging and response to treatment evaluated by FDG PET/CT. We report the case of a 28-year-old patient concomitantly diagnosed of a Hodgkin lymphoma and active tuberculosis. Initial staging was difficult due to pulmonary and abdominal tuberculosis localization that induced FDG PET/CT hypermetabolism. Anti-tuberculosis treatment was first started, allowing secondary an early accurate Hodgkin lymphoma staging by FDG PET/CT. The patient was then treated by chemotherapy and radiotherapy. Helical TomoTherapy® was used with involved site (IS) irradiation volume was performed to decrease the high doses to organs-at-risk (OAR), especially lungs in this context of tuberculosis.

Keywords: Helical TomoTherapy®; Hodgkin lymphoma; Lymphome de Hodgkin; PET/CT; Tomothérapie; Tuberculose; tuberculosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Antitubercular Agents / therapeutic use
  • Bleomycin / administration & dosage
  • Colonic Diseases / complications
  • Colonic Diseases / diagnostic imaging
  • Colonic Diseases / drug therapy*
  • Colonic Diseases / metabolism
  • Dacarbazine / administration & dosage
  • Doxorubicin / administration & dosage
  • Hodgkin Disease / complications
  • Hodgkin Disease / diagnostic imaging
  • Hodgkin Disease / metabolism
  • Hodgkin Disease / therapy*
  • Humans
  • Lung
  • Lymph Nodes / diagnostic imaging
  • Lymph Nodes / metabolism
  • Male
  • Organs at Risk
  • Positron Emission Tomography Computed Tomography
  • Radiotherapy, Intensity-Modulated
  • Risk Assessment
  • Tomography, X-Ray Computed
  • Tuberculosis, Gastrointestinal / complications
  • Tuberculosis, Gastrointestinal / diagnostic imaging
  • Tuberculosis, Gastrointestinal / drug therapy*
  • Tuberculosis, Pulmonary / complications
  • Tuberculosis, Pulmonary / diagnostic imaging
  • Tuberculosis, Pulmonary / drug therapy*
  • Vinblastine / administration & dosage

Substances

  • Antitubercular Agents
  • Bleomycin
  • Vinblastine
  • Dacarbazine
  • Doxorubicin

Supplementary concepts

  • ABVD protocol