New advances in the development of sarcoidosis models: a synopsis of a symposium sponsored by the Foundation for Sarcoidosis Research

Jacobo Sellares; Irina Strambu; Elliot D Crouser; Marina A Freudenberg; Mridu Gulati; Simon Hart; Erika Herzog; Martin Kolb; Thomas Weichhart; Wonder P Drake; Ginger Spitzer; Noopur Singh; Daniel A Culver

doi:10.36141/svdld.v35i1.7032

New advances in the development of sarcoidosis models: a synopsis of a symposium sponsored by the Foundation for Sarcoidosis Research

Sarcoidosis Vasc Diffuse Lung Dis. 2018;35(1):2-4. doi: 10.36141/svdld.v35i1.7032. Epub 2018 Apr 28.

Authors

Jacobo Sellares^{1

2

3}, Irina Strambu⁴, Elliot D Crouser⁵, Marina A Freudenberg⁶, Mridu Gulati⁷, Simon Hart⁸, Erika Herzog⁷, Martin Kolb⁹, Thomas Weichhart¹⁰, Wonder P Drake¹¹, Ginger Spitzer¹², Noopur Singh¹², Daniel A Culver¹³

Affiliations

¹ Programa Multidisciplinar de Enfermedades Pulmonares Intersticiales DIfusas. Servei de Pneumologia. Hospital Clínic. Barcelona, Spain.
² CiBER Enfermedades Respiratorias, Spain.
³ Institut Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
⁴ Pulmonology Department, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.
⁵ Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, the Dorothy M. Davis Heart and Lung Research Institute, the Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
⁶ Department of Pneumology, Centre for Medicine, Medical Centre - University of Freiburg, Freiburg, Germany.
⁷ Yale University School of Medicine, New Haven, Connecticut, USA.
⁸ Respiratory Research Group, Hull York Medical School, Castle Hill Hospital, Cottingham, United Kingdom.
⁹ Division of Respirology, McMaster University, Hamilton, Ontario, Canada.
¹⁰ Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria.
¹¹ Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA.
¹² Foundation for Sarcoidosis Research, Chicago, IL, USA.
¹³ Department of Pulmonary Medicine and Department of Pathobiology, Respiratory Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Abstract

Sarcoidosis is a complex disease with variable phenotypes that will require a multisystem approach to understand pathophysiology. One of the most challenging problems in sarcoidosis research is the absence of valid and widely accepted experimental models that accurately simulate human disease. The Foundation of Sarcoidosis Research (FSR) has funded five projects for the development of novel experimental models for sarcoidosis, presented and discussed in a workshop organized during the European Respiratory Society Congress held in Milan from September 9^th to 13^th. The experimental, in vivo or in sillico models presented may be quite helpful for investigating specific pathogenic and therapeutic questions, addressing especially severe forms of sarcoidosis. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 2-4).

Keywords: models; pathogenesis; sarcoidosis.

Publication types

Editorial