Wilms tumors and their precursors: Radiological diagnosis versus histology

Pediatr Blood Cancer. 2020 Sep;67(9):e28414. doi: 10.1002/pbc.28414. Epub 2020 Jun 22.

Abstract

The radiological distinction of Wilms tumor (WT) nodules from nephrogenic rests (NR) in patients with multifocal unilateral WT or bilateral disease is challenging. The study aims to compare the radiology assessment of kidney nodules with their final histology in 48 patients. The final histology of 118 nodules corresponded to the initial radiological diagnosis while 40 (25%) nodules were misdiagnosed, 20 being initially diagnosed WT on imaging were proved to be NR at histology. The size of nodules at diagnosis might help to distinguish WT from NR before surgery. Homogeneity did not seem to be a key feature.

Keywords: Wilms tumor; histology; nephrogenic rests; radiology.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Kidney / diagnostic imaging*
  • Kidney / pathology*
  • Kidney Neoplasms / diagnostic imaging*
  • Kidney Neoplasms / pathology*
  • Male
  • Retrospective Studies
  • Wilms Tumor / diagnostic imaging*
  • Wilms Tumor / pathology*