Posterior migration of lens fragments into the vitreous cavity is a rare complication of cataract surgery. Sight-threatening sequelae, including persistent intraocular inflammation, secondary glaucoma, corneal edema, cystoid macular edema and retinal detachment, can occur as a result of this complication. As such, judicious intra-operative and post-operative management must be employed to reduce the risk of complications in the setting of retained lens fragments. This often requires the collaboration of anterior and posterior segment surgeons.