Blastic transformation of BCR-ABL1 positive chronic myeloid leukaemia through acquisition of CBFB-MYH11 and mutant KIT

Br J Haematol. 2020 Sep;190(6):e339-e343. doi: 10.1111/bjh.16904. Epub 2020 Jun 24.
No abstract available

Keywords: BCR/ABL; CML; acute leukaemia; chronic leukaemia; haematological malignancies.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blast Crisis* / drug therapy
  • Blast Crisis* / genetics
  • Blast Crisis* / metabolism
  • Blast Crisis* / pathology
  • Fusion Proteins, bcr-abl* / genetics
  • Fusion Proteins, bcr-abl* / metabolism
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / genetics
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / metabolism
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / pathology
  • Male
  • Oncogene Proteins, Fusion* / genetics
  • Oncogene Proteins, Fusion* / metabolism
  • Proto-Oncogene Proteins c-kit* / genetics
  • Proto-Oncogene Proteins c-kit* / metabolism
  • Pyrimidines / administration & dosage*

Substances

  • BCR-ABL1 fusion protein, human
  • CBFbeta-MYH11 fusion protein
  • Oncogene Proteins, Fusion
  • Pyrimidines
  • KIT protein, human
  • Proto-Oncogene Proteins c-kit
  • Fusion Proteins, bcr-abl
  • nilotinib