Deep Sequencing of Varicella-Zoster Virus in Aqueous Humor From a Patient With Acute Retinal Necrosis Presenting With Acute Glaucoma

Joanna von Hofsten; Johan Ringlander; Peter Norberg; Madeleine Zetterberg; Maria Andersson; Magnus Lindh; Tomas Bergström

doi:10.1093/ofid/ofaa198

Deep Sequencing of Varicella-Zoster Virus in Aqueous Humor From a Patient With Acute Retinal Necrosis Presenting With Acute Glaucoma

Open Forum Infect Dis. 2020 May 26;7(6):ofaa198. doi: 10.1093/ofid/ofaa198. eCollection 2020 Jun.

Authors

Joanna von Hofsten^{1

2}, Johan Ringlander³, Peter Norberg³, Madeleine Zetterberg^{1

4}, Maria Andersson³, Magnus Lindh³, Tomas Bergström³

Affiliations

¹ Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
² Department of Ophthalmology, Halland Hospital Halmstad, Halmstad, Sweden.
³ Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Sweden.
⁴ Department of Ophthalmology, Sahlgrenska University Hospital, Mölndal, Gothenburg, Sweden.

Abstract

We report a case of acute retinal necrosis presenting with acute glaucoma preceding inflammatory signs by several days. High-throughput sequencing on aqueous humor revealed a low-level diversity in the viral genome comparable to diversity seen in cutaneous vesicles in contrast to high diversity in encephalitis.

Keywords: acute retinal necrosis; aqueous humor; high-throughput sequencing; varicella zoster virus.