Abstract
Objective:
To investigate the relationship between asthma and COVID-19.
Methods:
We searched the existing literature and researches to analyze the possible reasons.
Results:
The possible reasons for the very low COVID-19 infection in asthma patients in China may be as follows: the expression of ACE2 in asthma patients is relatively low; the use of ICS in asthma patients may have protective effect; data bias and ethnic differences are also possible reasons, too.
Conclusion:
The relationship between asthma patients and COVID-19 has not been completely clear, which needs further study.
Keywords:
COVID-19; China; ACE2; ICS; Mechanisms; SARS-Cov-2; TMPRSS2; asthma; epidemiology; infection; relationship.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Inhalation
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Angiotensin-Converting Enzyme 2 / metabolism
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Anti-Inflammatory Agents / administration & dosage
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Asthma / drug therapy
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Asthma / epidemiology*
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Asthma / immunology
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Asthma / pathology
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COVID-19 / epidemiology*
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COVID-19 / immunology
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COVID-19 / prevention & control
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COVID-19 / virology
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China / epidemiology
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Comorbidity
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Disease Susceptibility / immunology
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Glucocorticoids / administration & dosage
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Humans
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Incidence
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Lung / immunology
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Lung / pathology
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Lung / virology
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Risk Assessment / statistics & numerical data
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Risk Factors
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SARS-CoV-2 / immunology
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SARS-CoV-2 / pathogenicity*
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Serine Endopeptidases / metabolism
Substances
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Anti-Inflammatory Agents
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Glucocorticoids
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ACE2 protein, human
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Angiotensin-Converting Enzyme 2
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Serine Endopeptidases
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TMPRSS2 protein, human