Estimating lung cancer and cardiovascular mortality in female breast cancer patients receiving radiotherapy

Thomas Mulliez; Kurt Barbé; Mark de Ridder

doi:10.1016/j.radonc.2020.03.022

Estimating lung cancer and cardiovascular mortality in female breast cancer patients receiving radiotherapy

Radiother Oncol. 2020 Nov:152:111-116. doi: 10.1016/j.radonc.2020.03.022. Epub 2020 Mar 26.

Authors

Thomas Mulliez¹, Kurt Barbé², Mark de Ridder³

Affiliations

¹ Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Belgium; Department of Radiotherapy, Institut Andrée Dutreix, Dunkerque, France. Electronic address: thomasmulliez@hotmail.com.
² Department of Public Health; Research Group Biostatistics & Medical Informatics, Vrije Universiteit Brussel, Belgium.
³ Department of Radiotherapy, UZ Brussel, Vrije Universiteit Brussel, Belgium.

PMID: 32600774
DOI: 10.1016/j.radonc.2020.03.022

Abstract

By integrating data of the PLCO cancer screening trial, SCORE-risk charts and radiotherapy excess ratios, we were able to create risk charts estimating radiotherapy-induced lung cancer and cardiovascular mortality in female breast cancer patients. These risk models might be useful to individualize radiotherapy and optimize lung cancer and cardiovascular prevention and screening.

Keywords: Breast cancer; Lung cancer induction cardiovascular mortality; Radiotherapy.

MeSH terms

Breast Neoplasms* / radiotherapy
Cardiovascular Diseases* / etiology
Early Detection of Cancer
Female
Humans
Lung Neoplasms* / radiotherapy
Mass Screening