Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice

Shunpei Moriya; Hitoshi Takahashi; Daiki Masukawa; Makiko Yamada; Jun Ishigooka; Katsuji Nishimura

doi:10.1016/j.jphs.2020.06.005

Ziprasidone, a second-generation antipsychotic, affects core clock gene mRNA expression in mice

J Pharmacol Sci. 2020 Sep;144(1):57-59. doi: 10.1016/j.jphs.2020.06.005. Epub 2020 Jun 17.

Authors

Shunpei Moriya¹, Hitoshi Takahashi², Daiki Masukawa³, Makiko Yamada², Jun Ishigooka⁴, Katsuji Nishimura²

Affiliations

¹ Department of Psychiatry, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo, 162-8666, Japan; Department of Physiology, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, 890-8544, Japan. Electronic address: msmr9040psyg80@gmail.com.
² Department of Psychiatry, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo, 162-8666, Japan.
³ Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan.
⁴ Department of Psychiatry, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo, 162-8666, Japan; CNS Pharmacological Research Institute, Shibuya-ku, Tokyo, 151-0051, Japan.

PMID: 32624301
DOI: 10.1016/j.jphs.2020.06.005

Abstract

Some psychiatric diseases are associated with disruptions in the circadian clock system. Ziprasidone (ZIP), a second-generation antipsychotic, is widely used for psychiatry-related pharmacotherapy but its mechanism has not been clearly elucidated. We measured clock gene fluctuation patterns in the hippocampus and the amygdala in ZIP-treated mice. ZIP significantly increased Per1, Per2, and Bmal1 mRNA 2 h after the lights were turned off (ZT14) in the hippocampus, but not in the amygdala. These results suggest that ZIP might affect clock gene regulation, which could represent the pathway underlying symptom amelioration.

Keywords: Clock gene; Hippocampus; Ziprasidone.

MeSH terms

ARNTL Transcription Factors / genetics*
ARNTL Transcription Factors / metabolism*
Amygdala / metabolism
Animals
Antipsychotic Agents / pharmacology*
Biological Clocks / genetics*
Gene Expression / drug effects*
Gene Expression Regulation / drug effects*
Gene Expression Regulation / genetics*
Hippocampus / metabolism
Light
Male
Mice, Inbred C57BL
Period Circadian Proteins / genetics*
Period Circadian Proteins / metabolism*
Piperazines / pharmacology*
RNA, Messenger / genetics*
RNA, Messenger / metabolism*
Thiazoles / pharmacology*

Substances

ARNTL Transcription Factors
Antipsychotic Agents
Bmal1 protein, mouse
Per1 protein, mouse
Per2 protein, mouse
Period Circadian Proteins
Piperazines
RNA, Messenger
Thiazoles
ziprasidone