Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region

Proc Natl Acad Sci U S A. 1988 Nov;85(21):8161-5. doi: 10.1073/pnas.85.21.8161.

Abstract

A variable region (V delta 5) of the T-cell receptor (TcR) delta chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3' of the constant region (C delta) element. The V delta 5 coding sequence is in a transcriptional orientation opposite the J delta (joining region) and C delta coding elements and rearranges by inversion. The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises the entire 3' untranslated region. In this respect, C delta resembles C alpha rather than C beta or C gamma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Genes, Immunoglobulin*
  • Immunoglobulin Constant Regions / genetics*
  • Immunoglobulin Variable Region / genetics*
  • Mice
  • Molecular Sequence Data
  • Receptors, Antigen, T-Cell / genetics
  • T-Lymphocytes / immunology*

Substances

  • Immunoglobulin Constant Regions
  • Immunoglobulin Variable Region
  • Receptors, Antigen, T-Cell

Associated data

  • GENBANK/M23381
  • GENBANK/M23382