Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production

Signal Transduct Target Ther. 2020 Jul 8;5(1):121. doi: 10.1038/s41392-020-00237-0.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / ethnology
  • Adenoma / genetics
  • Adenoma / pathology
  • Angiotensin-Converting Enzyme 2
  • Asian People
  • Basigin / genetics
  • Basigin / metabolism
  • Betacoronavirus / genetics*
  • Betacoronavirus / metabolism
  • Betacoronavirus / pathogenicity
  • COVID-19
  • Cathepsin B / genetics
  • Cathepsin B / metabolism
  • Cathepsin L / genetics
  • Cathepsin L / metabolism
  • Colon / metabolism
  • Colon / pathology
  • Colon / virology*
  • Colorectal Neoplasms / ethnology
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / pathology
  • Coronavirus Infections / ethnology
  • Coronavirus Infections / genetics*
  • Coronavirus Infections / pathology
  • Coronavirus Infections / virology
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology
  • Epithelial Cells / virology
  • Furin / genetics
  • Furin / metabolism
  • Host-Pathogen Interactions / genetics*
  • Humans
  • Interleukin-6 / blood
  • Interleukin-6 / genetics
  • Pandemics
  • Peptidyl-Dipeptidase A / genetics
  • Peptidyl-Dipeptidase A / metabolism
  • Pneumonia, Viral / ethnology
  • Pneumonia, Viral / genetics*
  • Pneumonia, Viral / pathology
  • Pneumonia, Viral / virology
  • Receptors, Virus / genetics*
  • Receptors, Virus / metabolism
  • SARS-CoV-2
  • Serine Endopeptidases / genetics
  • Serine Endopeptidases / metabolism
  • Severity of Illness Index
  • Single-Cell Analysis
  • Transcriptome*
  • Tumor Necrosis Factor-alpha / blood
  • Tumor Necrosis Factor-alpha / genetics
  • Virus Internalization

Substances

  • BSG protein, human
  • IL6 protein, human
  • Interleukin-6
  • Receptors, Virus
  • Tumor Necrosis Factor-alpha
  • Basigin
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2
  • Serine Endopeptidases
  • TMPRSS2 protein, human
  • FURIN protein, human
  • Furin
  • CTSB protein, human
  • Cathepsin B
  • CTSL protein, human
  • Cathepsin L