Inhibitors of the renin-angiotensin-aldosterone system and COVID-19 in critically ill elderly patients

Christian Jung; Raphael Romano Bruno; Bernhard Wernly; Michael Joannidis; Sandra Oeyen; Tilemachos Zafeiridis; Brian Marsh; Finn H Andersen; Rui Moreno; Ana Margarida Fernandes; Antonio Artigas; Bernardo Bollen Pinto; Joerg Schefold; Georg Wolff; Malte Kelm; Dylan W De Lange; Bertrand Guidet; Hans Flaatten; Jesper Fjølner; COVIP study group

doi:10.1093/ehjcvp/pvaa083

Inhibitors of the renin-angiotensin-aldosterone system and COVID-19 in critically ill elderly patients

Eur Heart J Cardiovasc Pharmacother. 2021 Jan 16;7(1):76-77. doi: 10.1093/ehjcvp/pvaa083.

Authors

Christian Jung¹, Raphael Romano Bruno¹, Bernhard Wernly², Michael Joannidis³, Sandra Oeyen⁴, Tilemachos Zafeiridis⁵, Brian Marsh⁶, Finn H Andersen^{7

8}, Rui Moreno⁹, Ana Margarida Fernandes⁹, Antonio Artigas¹⁰, Bernardo Bollen Pinto¹¹, Joerg Schefold¹², Georg Wolff¹, Malte Kelm¹, Dylan W De Lange¹³, Bertrand Guidet¹⁴, Hans Flaatten^{15

16}, Jesper Fjølner¹⁷; COVIP study group

Affiliations

¹ Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University Duesseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany.
² Department of Cardiology, Paracelsus Medical University, Müllner Hauptstraße 48, A-5020 Salzburg, Austria.
³ Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
⁴ Department of Intensive Care 1K12IC, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Gent, Belgium.
⁵ Intensive Care Unit, General Hospital of Larissa, Tsakalof 1, Larisa 412 21, Greece.
⁶ Mater Misericordiae University Hospital, Eccles St, Northside, Dublin 7, D07 R2WY, Ireland.
⁷ Department of Anaesthesia and Intensive Care, Ålesund Hospital, Åsehaugen 5, 6017 Ålesund, Norway.
⁸ Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Prinsesse Kristinas gate 3, 7030 Trondheim, Norway.
⁹ Unidade de Cuidados Intensivos Neurocríticos e Trauma, Hospital de São José, Centro Hospitalar Universitário de Lisboa Central, Faculdade de Ciências Médicas de Lisboa, Nova Médical School, R. José António Serrano, 1150-199 Lisboa, Portugal.
¹⁰ Department of Intensive Care Medicine, CIBER Enfermedades Respiratorias, Corporacion Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Parc Taulí, 1, 08208 Sabadell, Spain.
¹¹ Department of Acute Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205 Genève, Switzerland.
¹² Department of Intensive Care Medicine, Inselspital, Universitätsspital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland.
¹³ Department of Intensive Care Medicine, University Medical Center, University Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
¹⁴ Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, service de réanimation médicale, 184 Rue du Faubourg Saint-Antoine, Paris F-75012, France.
¹⁵ Department of Clinical Medecine, University of Bergen, Jonas Lies vei 65, 5021 Bergen, Norway.
¹⁶ Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway.
¹⁷ Department of Intensive Care, Aarhus University Hospital, Palle Juul-Jensens Blvd. 161, 8200 Aarhus N, Denmark.

No abstract available

Publication types

Multicenter Study

MeSH terms

Aged
Aged, 80 and over
Angiotensin Receptor Antagonists / therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
COVID-19 / mortality*
Critical Illness
Female
Humans
Intensive Care Units
Male
Prospective Studies
SARS-CoV-2*

Substances

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors

Associated data

ClinicalTrials.gov/NCT04321265