Abstract
In 2011, the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) initiated a joint project to establish guidelines for biomarker testing in patients with advanced non-small-cell lung cancer based on the information available at the time. As this field is constantly evolving, these guidelines were updated in 2012 and 2015 and now in 2019. Current evidence suggests it should be mandatory to test all patients with this kind of advanced lung cancer for EGFR and BRAF mutations, ALK and ROS1 rearrangements and PD-L1 expression. The growing need to study other emerging biomarkers has promoted the routine use of massive sequencing (next-generation sequencing, NGS). However, the coordination of every professional involved and the prioritisation of the most suitable tests and technologies for each case remain a challenge.
Keywords:
ALK; BRAF; Biomarcadores; Biomarkers; Cáncer de pulmón de célula no pequeña; EGFR; Non-small-cell lung cancer; PD-L1; ROS1.
Copyright © 2020 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.
Publication types
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Practice Guideline
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Review
MeSH terms
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Anaplastic Lymphoma Kinase / genetics
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B7-H1 Antigen / analysis
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / genetics*
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Biopsy
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Carcinoma, Non-Small-Cell Lung / chemistry
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Carcinoma, Non-Small-Cell Lung / genetics*
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Carcinoma, Non-Small-Cell Lung / pathology
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Consensus*
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ErbB Receptors / genetics
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Genetic Markers
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High-Throughput Nucleotide Sequencing
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Humans
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Liquid Biopsy
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Lung Neoplasms / chemistry
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Lung Neoplasms / genetics*
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Lung Neoplasms / pathology
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Medical Oncology
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Membrane Glycoproteins / genetics
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Mutation
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Pathology, Clinical
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Protein-Tyrosine Kinases / genetics
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins B-raf / genetics
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Proto-Oncogene Proteins c-met / genetics
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Proto-Oncogene Proteins c-ret / genetics
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Receptor, trkA / genetics
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Receptor, trkB / genetics
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Receptor, trkC / genetics
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Societies, Medical
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Spain
Substances
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B7-H1 Antigen
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Biomarkers, Tumor
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CD274 protein, human
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Genetic Markers
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Membrane Glycoproteins
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NTRK1 protein, human
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NTRK3 protein, human
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Proto-Oncogene Proteins
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ALK protein, human
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Anaplastic Lymphoma Kinase
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ErbB Receptors
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MET protein, human
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Protein-Tyrosine Kinases
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Proto-Oncogene Proteins c-met
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Proto-Oncogene Proteins c-ret
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RET protein, human
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ROS1 protein, human
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Receptor, trkA
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Receptor, trkB
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Receptor, trkC
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tropomyosin-related kinase-B, human
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BRAF protein, human
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Proto-Oncogene Proteins B-raf