Autophagy and Alzheimer's Disease

Sheng Chen; Qinming Zhou; You Ni; Weidong Le

doi:10.1007/978-981-15-4272-5_1

Autophagy and Alzheimer's Disease

Adv Exp Med Biol. 2020:1207:3-19. doi: 10.1007/978-981-15-4272-5_1.

Authors

Sheng Chen¹, Qinming Zhou¹, You Ni¹, Weidong Le²

Affiliations

¹ Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
² Liaoning Provincial Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China. wdle@sibs.ac.cn.

PMID: 32671736
DOI: 10.1007/978-981-15-4272-5_1

Abstract

Alzheimer's disease (AD) is the most common type of dementia and is characterized by progressive cognitive decline. Increasing evidence has demonstrated that the autophagic process plays an important role in AD. In this chapter, we will discuss the role of autophagy in the pathogenesis of AD and other types of dementia, including dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), vascular dementia (VD) and prion diseases. In addition, we will discuss autophagy-targeted therapies as future treatments for AD.

Keywords: Alzheimer’s disease; Autophagy; Dementia.

Publication types

Review

MeSH terms

Alzheimer Disease*
Autophagy*
Dementia, Vascular
Frontotemporal Dementia
Humans
Lewy Body Disease