Use of cardiac magnetic resonance to detect changes in metabolism in heart failure

William D Watson; Jack J J Miller; Andrew Lewis; Stefan Neubauer; Damian Tyler; Oliver J Rider; Ladislav Valkovič

doi:10.21037/cdt.2019.12.13

Use of cardiac magnetic resonance to detect changes in metabolism in heart failure

Cardiovasc Diagn Ther. 2020 Jun;10(3):583-597. doi: 10.21037/cdt.2019.12.13.

Authors

William D Watson¹, Jack J J Miller^{1

2

3}, Andrew Lewis¹, Stefan Neubauer¹, Damian Tyler^{1

2}, Oliver J Rider¹, Ladislav Valkovič^{1

4}

Affiliations

¹ Oxford Centre for Clinical Magnetic Resonance Research, Clarendon Laboratory, University of Oxford, Oxford, UK.
² Department of Physiology, Anatomy and Genetics, Clarendon Laboratory, University of Oxford, Oxford, UK.
³ Department of Physics, Clarendon Laboratory, University of Oxford, Oxford, UK.
⁴ Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia.

Abstract

The heart has a massive adenosine triphosphate (ATP) requirement, produced from the oxidation of metabolic substrates such as fat and glucose. Magnetic resonance spectroscopy offers a unique opportunity to probe this biochemistry: ³¹Phosphorus spectroscopy can demonstrate the production of ATP and quantify levels of the transport molecule phosphocreatine while 13Carbon spectroscopy can demonstrate the metabolic fates of glucose in real time. These techniques allow the metabolic deficits in heart failure to be interrogated and can be a potential future clinical tool.

Keywords: Metabolism; cardiomyopathy; heart failure; magnetic resonance.

Publication types

Review

Abstract

Publication types

Grants and funding