Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design

Signal Transduct Target Ther. 2020 Jul 29;5(1):131. doi: 10.1038/s41392-020-00241-4.

Authors

Sheng Lin^#¹, Hua Chen^#¹, Fei Ye¹, Zimin Chen¹, Fanli Yang¹, Yue Zheng¹, Yu Cao^{1

2}, Jingxin Qiao¹, Shengyong Yang¹, Guangwen Lu³

Affiliations

¹ West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041, Chengdu, Sichuan, China.
² Disaster Medicine Center, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.
³ West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041, Chengdu, Sichuan, China. lugw@scu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemistry
Betacoronavirus / chemistry
Betacoronavirus / drug effects
Betacoronavirus / genetics
Betacoronavirus / ultrastructure*
COVID-19
Coronavirus Infections / drug therapy
Coronavirus Infections / genetics
Coronavirus Infections / virology*
Crystallography, X-Ray
Drug Design
Humans
Methyltransferases
Pandemics
Pneumonia, Viral / drug therapy
Pneumonia, Viral / genetics
Pneumonia, Viral / virology*
Protein Conformation / drug effects
S-Adenosylmethionine / chemistry
SARS-CoV-2
Viral Nonstructural Proteins / antagonists & inhibitors
Viral Nonstructural Proteins / chemistry*
Viral Nonstructural Proteins / ultrastructure
Viral Regulatory and Accessory Proteins / antagonists & inhibitors
Viral Regulatory and Accessory Proteins / chemistry*
Viral Regulatory and Accessory Proteins / ultrastructure
tRNA Methyltransferases / antagonists & inhibitors
tRNA Methyltransferases / chemistry

Substances

Antiviral Agents
NSP10 protein, SARS-CoV-2
NSP16 protein, SARS-CoV-2
Viral Nonstructural Proteins
Viral Regulatory and Accessory Proteins
S-Adenosylmethionine
Methyltransferases
tRNA Methyltransferases