Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation

Signal Transduct Target Ther. 2020 Jul 29;5(1):133. doi: 10.1038/s41392-020-00255-y.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzopyrenes / pharmacology
  • Cell Line, Tumor
  • Female
  • Humans
  • Neoplasm Proteins / metabolism*
  • Nuclear Proteins / metabolism*
  • Proteolysis / drug effects*
  • Snail Family Transcription Factors / metabolism*
  • Triple Negative Breast Neoplasms / drug therapy
  • Triple Negative Breast Neoplasms / metabolism*
  • Triple Negative Breast Neoplasms / pathology
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Benzopyrenes
  • Neoplasm Proteins
  • Nuclear Proteins
  • SNAI1 protein, human
  • Snail Family Transcription Factors
  • resistomycin
  • PELI1 protein, human
  • Ubiquitin-Protein Ligases