High-risk B-cell acute lymphoblastic leukaemia presenting with hypereosinophilia and acquiring a novel PAX5 fusion on relapse

Barbara J McClure; Susan L Heatley; Jacqueline Rehn; James Breen; Rosemary Sutton; Timothy P Hughes; Ram Suppiah; Tamas Revesz; Michael Osborn; Daniel White; David T Yeung; Deborah L White

doi:10.1111/bjh.17002

High-risk B-cell acute lymphoblastic leukaemia presenting with hypereosinophilia and acquiring a novel PAX5 fusion on relapse

Br J Haematol. 2020 Oct;191(2):301-304. doi: 10.1111/bjh.17002. Epub 2020 Jul 30.

Authors

Barbara J McClure^{1

2}, Susan L Heatley^{1

2

3}, Jacqueline Rehn^{1

4}, James Breen^{4

5

6}, Rosemary Sutton^{3

7

8

9}, Timothy P Hughes^{1

2

9

10}, Ram Suppiah¹¹, Tamas Revesz^{3

11

12}, Michael Osborn^{3

13

9

11}, Daniel White^{4

11}, David T Yeung^{1

2

9}, Deborah L White^{1

2

3

13

12

14}

Affiliations

¹ Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
² School of Medicine, University of Adelaide, Adelaide, SA, Australia.
³ Australian and New Zealand Children's Oncology Group (ANZCHOG), Clayton, VIC, Australia.
⁴ Faculty of Health and Medical Science, University of Adelaide, Adelaide, SA, Australia.
⁵ Computational and Systems Biology Program, SAHMRI, Adelaide, SA, Australia.
⁶ Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
⁷ Molecular Diagnostics, Children's Cancer Institute, Sydney, NSW, Australia.
⁸ School of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia.
⁹ Department of Haematology, Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia.
¹⁰ Australasian Leukaemia and Lymphoma Group, North Adelaide, SA, Australia.
¹¹ Women's and Children's Hospital, North Adelaide, SA, Australia.
¹² School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.
¹³ Australian Genomics Health Alliance (AGHA), Parkville, VIC, Australia.
¹⁴ School of Pediatrics, University of Adelaide, Adelaide, SA, Australia.

PMID: 32731299
DOI: 10.1111/bjh.17002

No abstract available

Keywords: B-ALL; Leukaemia; PAX5; Ph-like; hypereosinophilia.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Humans
Hypereosinophilic Syndrome* / genetics
Hypereosinophilic Syndrome* / metabolism
Hypereosinophilic Syndrome* / pathology
Immunoglobulin Heavy Chains* / genetics
Immunoglobulin Heavy Chains* / metabolism
Interleukin-3* / genetics
Interleukin-3* / metabolism
Male
Oncogene Proteins, Fusion* / genetics
Oncogene Proteins, Fusion* / metabolism
PAX5 Transcription Factor* / genetics
PAX5 Transcription Factor* / metabolism
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / metabolism
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / pathology

Substances

IL3 protein, human
Immunoglobulin Heavy Chains
Interleukin-3
Oncogene Proteins, Fusion
PAX5 Transcription Factor
PAX5 protein, human

Publication types

MeSH terms

Substances

Grants and funding