Dysregulated adaptive immune response contributes to severe COVID-19

Kuai Yu; Jingjing He; Yongjian Wu; Baosong Xie; Xuefei Liu; Bo Wei; Haibo Zhou; Bingliang Lin; Zhixiang Zuo; Wen Wen; Wenxiong Xu; Bin Zou; Lai Wei; Xi Huang; Penghui Zhou

doi:10.1038/s41422-020-0391-9

Dysregulated adaptive immune response contributes to severe COVID-19

Cell Res. 2020 Sep;30(9):814-816. doi: 10.1038/s41422-020-0391-9. Epub 2020 Aug 5.

Authors

Kuai Yu^#¹, Jingjing He^#¹, Yongjian Wu^#², Baosong Xie^#³, Xuefei Liu^#¹, Bo Wei^#^{4

5}, Haibo Zhou⁶, Bingliang Lin⁷, Zhixiang Zuo¹, Wen Wen⁸, Wenxiong Xu⁷, Bin Zou⁹, Lai Wei¹⁰, Xi Huang¹¹, Penghui Zhou¹²

Affiliations

¹ State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, China.
² Center for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, 519000, China.
³ Department of Pulmonary and Critical Care Medicine, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian, 350001, China.
⁴ Infectious Disease Department, The Second Affiliated Hospital of Naval Military Medical University, Shanghai, 200003, China.
⁵ Huoshenshan Hospital, Wuhan, Hubei, 430000, China.
⁶ The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong, 511500, China.
⁷ Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510630, China.
⁸ Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, China.
⁹ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
¹⁰ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China. weil9@mail.sysu.edu.cn.
¹¹ Center for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, 519000, China. huangxi6@mail.sysu.edu.cn.
¹² State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, China. zhouph@sysucc.org.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adaptive Immunity*
Betacoronavirus / immunology*
COVID-19
Coronavirus Infections / immunology*
Coronavirus Infections / pathology
Coronavirus Infections / therapy
Humans
Immunoglobulins, Intravenous / immunology
Immunoglobulins, Intravenous / therapeutic use
Lymphocyte Activation
Pandemics
Pneumonia, Viral / immunology*
Pneumonia, Viral / pathology
Pneumonia, Viral / therapy
Protein Precursors / immunology
SARS-CoV-2
T-Lymphocytes / immunology
Thymalfasin / immunology
Thymalfasin / therapeutic use
Thymosin / analogs & derivatives
Thymosin / immunology

Substances

Immunoglobulins, Intravenous
Protein Precursors
prothymosin alpha
Thymosin
Thymalfasin