Using Whole-genome Sequencing to Determine the Timing of Secondary Tuberculosis in British Columbia, Canada

Kamila Romanowski; Benjamin Sobkowiak; Jennifer L Guthrie; Victoria J Cook; Jennifer L Gardy; James C Johnston

doi:10.1093/cid/ciaa1224

Using Whole-genome Sequencing to Determine the Timing of Secondary Tuberculosis in British Columbia, Canada

Clin Infect Dis. 2021 Aug 2;73(3):535-537. doi: 10.1093/cid/ciaa1224.

Authors

Kamila Romanowski^{1

2}, Benjamin Sobkowiak^{1

2}, Jennifer L Guthrie², Victoria J Cook^{1

2}, Jennifer L Gardy², James C Johnston^{1

2}

Affiliations

¹ British Columbia Centre for Disease Control, Vancouver, Canada.
² University of British Columbia, Vancouver, Canada.

Abstract

Combined with epidemiological data, whole-genome sequencing (WGS) can help better resolve individual tuberculosis (TB) transmission events to a degree not possible with traditional genotyping. We combine WGS data with patient-level data to calculate the timing of secondary TB among contacts of people diagnosed with active TB in British Columbia, Canada.

Keywords: epidemiology; tuberculosis; whole-genome sequencing.

MeSH terms

British Columbia / epidemiology
Humans
Mycobacterium tuberculosis* / genetics
Tuberculosis* / epidemiology
Whole Genome Sequencing