Abstract
An imidazole modified Pt(iv) prodrug with a long lipid tail can assemble into multi-stage pH responsive nanoparticles via electrostatic complexation with a negatively charged hydrophilic polymer. This strategy could overcome cisplatin resistance significantly.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Cisplatin / chemistry
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Cisplatin / pharmacology*
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Dose-Response Relationship, Drug
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Drug Resistance, Neoplasm / drug effects*
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Drug Screening Assays, Antitumor
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Humans
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Hydrogen-Ion Concentration
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Hydrophobic and Hydrophilic Interactions
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Imidazoles / chemistry
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Imidazoles / pharmacology*
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Lipids / chemistry
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Lipids / pharmacology
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Molecular Structure
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Nanoparticles / chemistry*
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Particle Size
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Platinum / chemistry
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Platinum / pharmacology*
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Prodrugs / chemical synthesis
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Prodrugs / chemistry
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Prodrugs / pharmacology*
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Static Electricity
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Surface Properties
Substances
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Antineoplastic Agents
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Imidazoles
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Lipids
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Prodrugs
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Platinum
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imidazole
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Cisplatin