Combined imaging of potassium and sodium in human skeletal muscle tissue at 7 T

Abstract

Purpose: To validate the feasibility of quantitative combined potassium (³⁹ K) and sodium (²³ Na) MRI in human calf muscle tissue, as well as to evaluate the reproducibility of the apparent tissue potassium concentration (aTPC) and apparent tissue sodium concentration (aTSC) determination in healthy muscle tissue.

Methods: Quantitative ²³ Na and ³⁹ K MRI acquisition protocols were implemented on a 7 T MR system. A double-resonant ²³ Na/³⁹ K birdcage RF coil was used. Measurements of human lower leg were performed in a total acquisition time of TA_Na = 10:54 min/TA_K = 8:06 min and using a nominal spatial resolution of 2.5 × 2.5 × 15 mm³ /7.5 × 7.5 × 30 mm³ for ²³ Na/³⁹ K MRI. Two aTSC and aTPC examinations in muscle tissue were performed during the same day on 10 healthy subjects.

Results: The proposed acquisition and postprocessing workflow for ²³ Na and ³⁹ K MRI data sets provided reproducible aTSC and aTPC measurements. In human calf muscle tissue, the coefficient of variation between scan and re-scan was 5.7% for both aTSC and aTPC determination. Overall, mean values of aTSC = (17 ± 1) mM and aTPC = (85 ± 5) mM were measured. Moreover, for ³⁹ K in calf muscle tissue, $T_2^{\ast }$ components of $T_{2f}^{\ast }$ = (1.2 ± 0.2) ms and $T_{2s}^{\ast }$ = (7.9 ± 0.9) ms, as well as a residual quadrupolar interaction of $\overline{{\omega }_q}$ = (143 ± 17) Hz, were determined. The fraction of the fast component was f = (58 ± 4)%.

Conclusion: Using the presented measurement and postprocessing approach, a reproducible aTSC and aTPC determination using ²³ Na and ³⁹ K MRI at 7 T in human skeletal muscle tissue is feasible in clinically acceptable acquisition durations.

Keywords: 7 T; potassium MRI; sodium MRI; tissue potassium concentration; tissue sodium concentration; ultrahigh field strengths.