NETosis Is Required for S100A8/A9-Induced Granulopoiesis After Myocardial Infarction

Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2805-2807. doi: 10.1161/ATVBAHA.120.314807. Epub 2020 Sep 3.

Affiliations

¹ Division of Cardiac Surgery, Department of Surgery, Ohio State University Wexner Medical Center, Columbus (P.R.N., G.S., R.M.J., J.J., B.A.).
² Division of Cardiovascular Medicine, Department of Medicine, University of Kentucky, Lexington (M.A.-A., L.C., A.A.-L.).
³ Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia (G.P., A.J.M.).

Abstract

Keywords: bone marrow; inflammation; myocardial infarction; neutrophils; upregulation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calgranulin A / blood
Calgranulin A / metabolism*
Calgranulin B / blood
Calgranulin B / metabolism*
Case-Control Studies
Disease Models, Animal
Extracellular Traps / metabolism*
Humans
Leukopoiesis*
Male
Mice, Inbred C57BL
Mice, Knockout
Myocardial Infarction / immunology
Myocardial Infarction / metabolism*
Myocardial Infarction / pathology
Neutrophils / immunology
Neutrophils / metabolism*
Neutrophils / pathology
Non-ST Elevated Myocardial Infarction / blood
Protein-Arginine Deiminases / deficiency
Protein-Arginine Deiminases / genetics
ST Elevation Myocardial Infarction / blood
Signal Transduction
Time Factors

Substances

Calgranulin A
Calgranulin B
S100A8 protein, human
S100A9 protein, human
S100A9 protein, mouse
S100a8 protein, mouse
Padi4 protein, mouse
Protein-Arginine Deiminases

Grants and funding