Diagnostic Considerations in the Evaluation of Large B-Cells on Lymph Node Cytology Specimens

Daniel F Boyer; Sarah Choi; Winston Lee; Shannon Carty; Bryan L Betz; Noah Brown; Madelyn Lew

doi:10.1159/000510322

Diagnostic Considerations in the Evaluation of Large B-Cells on Lymph Node Cytology Specimens

Acta Cytol. 2021;65(1):105-110. doi: 10.1159/000510322. Epub 2020 Sep 3.

Authors

Daniel F Boyer¹, Sarah Choi¹, Winston Lee¹, Shannon Carty², Bryan L Betz¹, Noah Brown¹, Madelyn Lew³

Affiliations

¹ Department of Pathology, University of Michigan Hospital and Health System, Ann Arbor, Michigan, USA.
² Department of Internal Medicine, University of Michigan Hospital and Health System, Ann Arbor, Michigan, USA.
³ Department of Pathology, University of Michigan Hospital and Health System, Ann Arbor, Michigan, USA, lewm@med.umich.edu.

PMID: 32882689
DOI: 10.1159/000510322

Abstract

Fine needle aspiration (FNA) has become increasingly popular in the evaluation of lymph nodes for lymphoproliferative disorders, but there are limitations to accurate subclassification of lymphoma using morphology alone. This case aims to expand diagnostic considerations of large B-cell populations identified on FNA material. We also address the significance of Epstein-Barr virus (EBV) DNA in the workup of patients with suspected lymphoma by FNA.

Keywords: Angioimmunoblastic T-cell lymphoma; Fine needle aspiration; Immunoblastic proliferation; Large B-cells; Lymph node cytology; Lymphoma.

Publication types

Case Reports

MeSH terms

Aged
B-Lymphocytes / pathology*
Biopsy, Fine-Needle / methods
Cytodiagnosis / methods
Humans
Lymph Nodes / pathology*
Lymphoma, B-Cell / diagnosis*
Lymphoma, B-Cell / pathology*
Male