Huntington's Disease: Les Jeux Sont Faits?

Edith L Pfister; Neil Aronin

doi:10.1016/j.molmed.2020.08.004

Huntington's Disease: Les Jeux Sont Faits?

Trends Mol Med. 2020 Oct;26(10):889-890. doi: 10.1016/j.molmed.2020.08.004. Epub 2020 Sep 4.

Authors

Edith L Pfister¹, Neil Aronin²

Affiliations

¹ Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
² Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: neil.aronin@umassmed.edu.

PMID: 32893090
DOI: 10.1016/j.molmed.2020.08.004

Abstract

In a meticulous study, Humbert, Durr, and colleagues showed evidence for aberrant neurodevelopment in both Huntington's disease (HD) and mouse models of HD. We consider the implications of prenatal pathological changes for the onset and progression of HD and their relatedness to current therapeutic plans.

Keywords: Huntington’s disease; neurodevelopment.

Publication types

Comment

MeSH terms

Animals
Disease Progression
Humans
Huntington Disease*
Mice