Nodular Spindle Cell Vascular Transformation in Pelvic Lymph Nodes With Discovered on GIST1 (DOG1) Positivity Mimicking Metastatic Gastrointestinal Stromal Tumor

Jocelyn Chai; Trevor Hamilton; Cheng Han-Lee; Xiaolan Feng

doi:10.7759/cureus.9632

Nodular Spindle Cell Vascular Transformation in Pelvic Lymph Nodes With Discovered on GIST1 (DOG1) Positivity Mimicking Metastatic Gastrointestinal Stromal Tumor

Cureus. 2020 Aug 9;12(8):e9632. doi: 10.7759/cureus.9632.

Authors

Jocelyn Chai¹, Trevor Hamilton^{2

3}, Cheng Han-Lee^{4

5}, Xiaolan Feng⁶

Affiliations

¹ Internal Medicine, University of British Columbia, Vancouver, CAN.
² Surgery, University of British Columbia, Vancouver, CAN.
³ Surgery, British Columbia Cancer Agency, Vancouver, CAN.
⁴ Pathology, British Columbia Cancer Agency, Vancouver, CAN.
⁵ Pathology and Laboratory Medicine, University of British Columbia, Vancouver, CAN.
⁶ Medical Oncology, British Columbia Cancer Agency, Vancouver, CAN.

Abstract

We present a case report of vascular transformation of lymph node sinuses (VTS) of nodular spindle cell variant. This variation is a rare, benign entity previously described with histopathologic transformation of lymph node sinuses into spindle cell nodules with or without vascular channels and associated sinusoidal fibrosis. This case highlights the diagnostic pitfall of discovered on GIST1 (DOG1) immunohistochemical staining of this entity, contributing to the initial misdiagnosis as metastatic gastrointestinal stromal tumor (GIST). To our knowledge, this is the first reported case of a patient with VTS and DOG1 positivity.

Keywords: dog1; gist; immunohistochemistry; lymph nodes; vascular neoplasms.

Publication types

Case Reports