Update on serologic testing in COVID-19

Rafał Krajewski; Justyna Gołębiowska; Sebastian Makuch; Grzegorz Mazur; Siddarth Agrawal

doi:10.1016/j.cca.2020.09.015

Update on serologic testing in COVID-19

Clin Chim Acta. 2020 Nov:510:746-750. doi: 10.1016/j.cca.2020.09.015. Epub 2020 Sep 15.

Authors

Rafał Krajewski¹, Justyna Gołębiowska¹, Sebastian Makuch², Grzegorz Mazur¹, Siddarth Agrawal³

Affiliations

¹ Department and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Poland.
² Department of Pathology, Wroclaw Medical University, Poland.
³ Department and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Poland; Department of Pathology, Wroclaw Medical University, Poland; Department of Cancer Prevention and Therapy, Wroclaw Medical University, Poland. Electronic address: siddarth@agrawal.pl.

Abstract

Serologic tests are one of the available diagnostic tools in COVID-19. Growing literature highlights their role in the clinical management of the disease. Unfortunately, due to the limited availability of commercial tests and the lack of reliable trials establishing the sensitivity and specificity of the diagnostic method, the clinical application of the test needs to be precisely determined. In this paper, we discuss the utility of anti-SARS-CoV-2 serology testing in a clinical setting and propose diagnostic algorithms that include serological tests in patients with confirmed or suspected COVID-19.

Keywords: COVID-19; Diagnostic algorithms; Public health; Serologic tests.

Publication types

Review

MeSH terms

Antibodies, Viral / blood
COVID-19
Coronavirus Infections / blood
Coronavirus Infections / diagnosis*
Coronavirus Infections / immunology
Humans
Pandemics
Pneumonia, Viral / blood
Pneumonia, Viral / diagnosis*
Pneumonia, Viral / immunology
Serologic Tests*

Substances

Antibodies, Viral